Evaluation in a Dog Model of Three Antimicrobial Glassy Coatings: Prevention of Bone Loss around Implants and Microbial Assessments
Identifieur interne : 000425 ( Pmc/Curation ); précédent : 000424; suivant : 000426Evaluation in a Dog Model of Three Antimicrobial Glassy Coatings: Prevention of Bone Loss around Implants and Microbial Assessments
Auteurs : Roberto L Pez-Píriz [Espagne] ; Eva Solá-Linares [Espagne] ; Mercedes Rodriguez-Portugal [Espagne] ; Beatriz Malpica [Espagne] ; Idoia Díaz-Güemes [Espagne] ; Silvia Enciso [Espagne] ; Leticia Esteban-Tejeda [Irlande (pays)] ; Belén Cabal [Espagne] ; Juan José Granizo [Espagne] ; José Serafín Moya [Espagne] ; Ram N Torrecillas [Espagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
The aim of the present study is to evaluate, in a ligature-induced peri-implantitis model, the efficacy of three antimicrobial glassy coatings in the prevention of biofilm formation, intrasulcular bacterial growth and the resulting peri-implant bone loss.
Mandibular premolars were bilaterally extracted from five beagle dogs. Four dental implants were inserted on each hemiarch. Eight weeks after, one control zirconia abutment and three with different bactericidal coatings (G1n-Ag, ZnO35, G3) were connected. After a plaque control period, bacterial accumulation was allowed and biofilm formation on abutments was observed by Scanning Electron Microscopy (SEM). Peri-implantitis was induced by cotton ligatures. Microbial samples and peri-implant crestal bone levels of all implant sites were obtained before, during and after the breakdown period.
During experimental induce peri-implantitis: colony forming units counts from intrasulcular microbial samples at implants with G1n-Ag coated abutment remained close to the basal inoculum; G3 and ZnO35 coatings showed similar low counts; and anaerobic bacterias counts at control abutments exhibited a logarithmic increase by more than 2. Bone loss during passive breakdown period was no statistically significant. Additional bone loss occurred during ligature-induce breakdown: 0.71 (SD 0.48) at G3 coating, 0.57 (SD 0.36) at ZnO35 coating, 0.74 (SD 0.47) at G1n-Ag coating, and 1.29 (SD 0.45) at control abutments; and statistically significant differences (p<0.001) were found. The lowest bone loss at the end of the experiment was exhibited by implants dressing G3 coated abutments (mean 2.1; SD 0.42).
Antimicrobial glassy coatings could be a useful tool to ward off, diminish or delay peri-implantitis progression.
Url:
DOI: 10.1371/journal.pone.0140374
PubMed: 26489088
PubMed Central: 4619200
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and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias</wicri:regionArea></affiliation></author><author><name sortKey="Sola Linares, Eva" sort="Sola Linares, Eva" uniqKey="Sola Linares E" first="Eva" last="Solá-Linares">Eva Solá-Linares</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Advance Surgery Center Institute (ICOA), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Advance Surgery Center Institute (ICOA), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Portugal, Mercedes" sort="Rodriguez Portugal, Mercedes" uniqKey="Rodriguez Portugal M" first="Mercedes" 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Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Minimally Invasive Surgery Center (CCMIJU), Cáceres</wicri:regionArea></affiliation></author><author><name sortKey="Enciso, Silvia" sort="Enciso, Silvia" uniqKey="Enciso S" first="Silvia" last="Enciso">Silvia Enciso</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Minimally Invasive Surgery Center (CCMIJU), Cáceres, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Minimally Invasive Surgery Center (CCMIJU), Cáceres</wicri:regionArea></affiliation></author><author><name sortKey="Esteban Tejeda, Leticia" sort="Esteban Tejeda, Leticia" uniqKey="Esteban Tejeda L" first="Leticia" last="Esteban-Tejeda">Leticia Esteban-Tejeda</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>School of Chemistry, Trinity College Dublin, College Green, Dublin 2, Ireland</addr-line></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Chemistry, Trinity College Dublin, College Green, Dublin 2</wicri:regionArea></affiliation></author><author><name sortKey="Cabal, Belen" sort="Cabal, Belen" uniqKey="Cabal B" first="Belén" last="Cabal">Belén Cabal</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias</wicri:regionArea></affiliation></author><author><name sortKey="Granizo, Juan Jose" sort="Granizo, Juan Jose" uniqKey="Granizo J" first="Juan José" last="Granizo">Juan José Granizo</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Preventive Medicine Unit, Infanta Mercedes Hospital, Parla, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Preventive Medicine Unit, Infanta Mercedes Hospital, Parla</wicri:regionArea></affiliation></author><author><name sortKey="Moya, Jose Serafin" sort="Moya, Jose Serafin" uniqKey="Moya J" first="José Serafín" last="Moya">José Serafín Moya</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias</wicri:regionArea></affiliation></author><author><name sortKey="Torrecillas, Ram N" sort="Torrecillas, Ram N" uniqKey="Torrecillas R" first="Ram N" last="Torrecillas">Ram N Torrecillas</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objectives</title><p>The aim of the present study is to evaluate, in a ligature-induced peri-implantitis model, the efficacy of three antimicrobial glassy coatings in the prevention of biofilm formation, intrasulcular bacterial growth and the resulting peri-implant bone loss.</p></sec><sec id="sec002"><title>Methods</title><p>Mandibular premolars were bilaterally extracted from five beagle dogs. Four dental implants were inserted on each hemiarch. Eight weeks after, one control zirconia abutment and three with different bactericidal coatings (G1n-Ag, ZnO35, G3) were connected. After a plaque control period, bacterial accumulation was allowed and biofilm formation on abutments was observed by Scanning Electron Microscopy (SEM). Peri-implantitis was induced by cotton ligatures. Microbial samples and peri-implant crestal bone levels of all implant sites were obtained before, during and after the breakdown period.</p></sec><sec id="sec003"><title>Results</title><p>During experimental induce peri-implantitis: colony forming units counts from intrasulcular microbial samples at implants with G1n-Ag coated abutment remained close to the basal inoculum; G3 and ZnO35 coatings showed similar low counts; and anaerobic bacterias counts at control abutments exhibited a logarithmic increase by more than 2. Bone loss during passive breakdown period was no statistically significant. Additional bone loss occurred during ligature-induce breakdown: 0.71 (SD 0.48) at G3 coating, 0.57 (SD 0.36) at ZnO35 coating, 0.74 (SD 0.47) at G1n-Ag coating, and 1.29 (SD 0.45) at control abutments; and statistically significant differences (p<0.001) were found. The lowest bone loss at the end of the experiment was exhibited by implants dressing G3 coated abutments (mean 2.1; SD 0.42).</p></sec><sec id="sec004"><title>Significance</title><p>Antimicrobial glassy coatings could be a useful tool to ward off, diminish or delay peri-implantitis progression.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Albrektsson, T" uniqKey="Albrektsson T">T Albrektsson</name></author><author><name sortKey="Zarb, G" uniqKey="Zarb G">G Zarb</name></author><author><name sortKey="Worthington, P" uniqKey="Worthington P">P Worthington</name></author><author><name sortKey="Eriksson, Ar" uniqKey="Eriksson A">AR Eriksson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roos, J" uniqKey="Roos J">J Roos</name></author><author><name sortKey="Sennerby, L" uniqKey="Sennerby L">L Sennerby</name></author><author><name sortKey="Lekholm, U" uniqKey="Lekholm U">U 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26489088</article-id><article-id pub-id-type="pmc">4619200</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0140374</article-id><article-id pub-id-type="publisher-id">PONE-D-15-13942</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Evaluation in a Dog Model of Three Antimicrobial Glassy Coatings: Prevention of Bone Loss around Implants and Microbial Assessments</article-title><alt-title alt-title-type="running-head">Antimicrobial Coatings in Implants</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>López-Píriz</surname><given-names>Roberto</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref rid="cor001" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Solá-Linares</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez-Portugal</surname><given-names>Mercedes</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Malpica</surname><given-names>Beatriz</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Díaz-Güemes</surname><given-names>Idoia</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Enciso</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Esteban-Tejeda</surname><given-names>Leticia</given-names></name><xref ref-type="aff" rid="aff005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cabal</surname><given-names>Belén</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Granizo</surname><given-names>Juan José</given-names></name><xref ref-type="aff" rid="aff006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Moya</surname><given-names>José Serafín</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Torrecillas</surname><given-names>Ramón</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Nanomaterials and Nanotechnology Research Center (CINN-CSIC), Universidad de Oviedo (UO), Principado de Asturias, San Martín del Rey Aurelio, Asturias, Spain</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Advance Surgery Center Institute (ICOA), Madrid, Spain</addr-line></aff><aff id="aff003"><label>3</label><addr-line>Private Practice in Dentistry, Madrid, Spain</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Minimally Invasive Surgery Center (CCMIJU), Cáceres, Spain</addr-line></aff><aff id="aff005"><label>5</label><addr-line>School of Chemistry, Trinity College Dublin, College Green, Dublin 2, Ireland</addr-line></aff><aff id="aff006"><label>6</label><addr-line>Preventive Medicine Unit, Infanta Mercedes Hospital, Parla, Spain</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Pérez</surname><given-names>M. A.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Zaragoza, SPAIN</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: RL BE BC JSM RT. Performed the experiments: RL ES MR BM ID SE. Analyzed the data: RL JG LE BC JSM RT. Contributed reagents/materials/analysis tools: RL ES ID SE LE BC JSM RT. Wrote the paper: RL BC JSM RT.</p></fn><corresp id="cor001">* E-mail: <email>lopezpiriz@gmail.com</email></corresp></author-notes><pub-date pub-type="epub"><day>21</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>10</volume><issue>10</issue><elocation-id>e0140374</elocation-id><history><date date-type="received"><day>31</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>24</day><month>9</month><year>2015</year></date></history><permissions><copyright-year>2015</copyright-year><copyright-holder>López-Píriz et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0140374.pdf"></self-uri><abstract><sec id="sec001"><title>Objectives</title><p>The aim of the present study is to evaluate, in a ligature-induced peri-implantitis model, the efficacy of three antimicrobial glassy coatings in the prevention of biofilm formation, intrasulcular bacterial growth and the resulting peri-implant bone loss.</p></sec><sec id="sec002"><title>Methods</title><p>Mandibular premolars were bilaterally extracted from five beagle dogs. Four dental implants were inserted on each hemiarch. Eight weeks after, one control zirconia abutment and three with different bactericidal coatings (G1n-Ag, ZnO35, G3) were connected. After a plaque control period, bacterial accumulation was allowed and biofilm formation on abutments was observed by Scanning Electron Microscopy (SEM). Peri-implantitis was induced by cotton ligatures. Microbial samples and peri-implant crestal bone levels of all implant sites were obtained before, during and after the breakdown period.</p></sec><sec id="sec003"><title>Results</title><p>During experimental induce peri-implantitis: colony forming units counts from intrasulcular microbial samples at implants with G1n-Ag coated abutment remained close to the basal inoculum; G3 and ZnO35 coatings showed similar low counts; and anaerobic bacterias counts at control abutments exhibited a logarithmic increase by more than 2. Bone loss during passive breakdown period was no statistically significant. Additional bone loss occurred during ligature-induce breakdown: 0.71 (SD 0.48) at G3 coating, 0.57 (SD 0.36) at ZnO35 coating, 0.74 (SD 0.47) at G1n-Ag coating, and 1.29 (SD 0.45) at control abutments; and statistically significant differences (p<0.001) were found. The lowest bone loss at the end of the experiment was exhibited by implants dressing G3 coated abutments (mean 2.1; SD 0.42).</p></sec><sec id="sec004"><title>Significance</title><p>Antimicrobial glassy coatings could be a useful tool to ward off, diminish or delay peri-implantitis progression.</p></sec></abstract><funding-group><funding-statement>This work was supported by the Spanish Ministry of Science and Innovation (MICINN) and The Spanish National Research Council (CSIC) under the projects MAT2012-38645 and 201360E012 respectively. B. Cabal acknowledges financial support from JAE-Doc program (CSIC, cofounded by FSE). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><fig-count count="9"></fig-count><table-count count="0"></table-count><page-count count="16"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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